Animal models of neuropsychiatric disorders

Animal models of epigenetic regulation in neuropsychiatric disorders.

Epigenetics describes the phenomenon of heritable changes in gene regulation that are governed by non-Mendelian processes, primarily through biochemical modifications to chromatin structure that occur during cell development and differentiation. Numerous lines of evidence link abnormal levels of chromatin modifications (either to DNA, histones, or both) in patients with a wide variety of diseas...

Ethopharmacology: Primate Models of Neuropsychiatric Disorders

chemical environment to which cells are exposed. Although there is some inherent instability in cell lines, their overall homogeneity allows a consistency and reproduceability unattainable in animal work. With recent protests from animal protection groups, there has been increased pressure to develop in vitro models for toxicity, mutagenicity, and carcinogenicity. R. Ian Freshney, who has done ...

Amygdalar Models of Neurological and Neuropsychiatric Disorders

Animal Models for Elucidation of the Mechanisms of Neuropsychiatric Disorders Induced by Sleep and Dietary Habits.

Numerous changes in human lifestyle in modern life increase the risk of disease. Especially, modern sleep and dietary habits are crucial factors affecting lifestyle disease. In terms of sleep, decreases in total sleep time and in rapid eye movement sleep time have been observed in attention-deficit/hyperactivity disorder (ADHD) patients. From a dietary perspective, mastication during eating has...

Gut Microbiota and Neuropsychiatric Disorders